Fig. 3: The role of EZH2 and BCL-6 interaction in terminal B-cell differentiation suppression. | Modern Pathology

Fig. 3: The role of EZH2 and BCL-6 interaction in terminal B-cell differentiation suppression.

From: Evolving insights into the genomic complexity and immune landscape of diffuse large B-cell lymphoma: opportunities for novel biomarkers

Fig. 3

BCL-6 cooperates with the histone methyltransferase EZH2 to maintain many gene regulatory elements in a bivalent chromatin state, thereby enforcing the germinal center (GC) phenotype while allowing signal-induced activation of certain genes. GC germinal center.

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