Fig. 4: Immune landscapes in DLBCL: inflamed phenotype, immune suppressed subtype. | Modern Pathology

Fig. 4: Immune landscapes in DLBCL: inflamed phenotype, immune suppressed subtype.

From: Evolving insights into the genomic complexity and immune landscape of diffuse large B-cell lymphoma: opportunities for novel biomarkers

Fig. 4

Mutations in NFkB, NOTCH2, and NOTCH1 among others in DLBCL, contribute to excessive cytokine secretion, which in turn attracts T-cells, and enhances the inflammatory microenvironment. However, high numbers of suppressive immune cells inactivating class I HLA or CD58 in the tumor microenvironment, cause T-cell exhaustion.

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