Table 1 Gleason score 8 patients stratified for individual Gleason score (GS).
All n = 140 | GS 3 + 5 n = 76 | GS 4 + 4 n = 46 | GS 5 + 3 n = 18 | P value | |
|---|---|---|---|---|---|
Age (years) | 64.7 (65.3; 61.4–68.5) | 64.3 (64.5; 60.7–68.2) | 65.6 (66.2; 62.4–69.2) | 64.5 (65.2; 60.4–67.2) | 0.46 |
PSA (ng/ml) | 12.9 (10.0; 7.2–16.0) | 12.5 (10.0; 7.4–15.0) | 11.5 (8.9; 6.9–16.0) | 18.5 (13.4; 8.8–26.8) | 0.07 |
pT-stage | |||||
T2 | 67 (48%) | 41 (54%) | 19 (41%) | 7 (39%) | 0.35 |
T3a | 44 (31%) | 19 (25%) | 19 (41%) | 6 (33%) | |
T3b/T4 | 29 (21%) | 16 (21%) | 8 (18%) | 5 (28%) | |
Overall cribriform | 87 (62%) | 36 (47%) | 43 (93%) | 8 (44%) | <0.001 |
Gleason pattern 4 | |||||
Small cribriform | 83 (59%) | 33 (43%) | 42 (91%) | 8 (44%) | <0.001 |
Large cribriform | 38 (27%) | 6 (8%) | 28 (61%) | 4 (22%) | <0.001 |
Intraductal carcinoma | 48 (34%) | 21 (28%) | 23 (50%) | 4 (22%) | 0.02 |
Gleason pattern 5 | |||||
Single cells and/or cords | 99 (71%) | 72 (95%) | 10 (22%) | 17 (94%) | <0.001 |
Small solid nests | 23 (16%) | 16 (21%) | 1 (2%) | 6 (33%) | 0.003 |
Medium to large solid fields | 15 (11%) | 4 (5%) | 5 (11%) | 6 (33%) | 0.006 |
Comedonecrosis | 9 (6%) | 2 (3%) | 7 (15%) | 0 | 0.02 |
Positive surgical margins | 68 (49%) | 40 (53%) | 20 (44%) | 8 (44%) | 0.58 |
Pelvic lymph node dissection | 91 (65%) | 47 (62%) | 29 (63%) | 15 (83%) | 0.22 |
Lymph node metastasis | 12 (13%) | 5 (11%) | 4 (14%) | 3 (20%) | 0.54 |
Biochemical recurrence | 68 (49%) | 31 (41%) | 29 (63%) | 8 (44%) | 0.05 |
Metastasis | 36 (26%) | 14 (18%) | 18 (39%) | 4 (22%) | 0.04 |
Disease-specific death | 12 (9%) | 4 (5%) | 7 (15%) | 1 (6%) | 0.17 |
