Table 2 Cases clinical features.

From: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

Case

MA

G

P

GA at delivery (weeks + days)

Days from COVID+ test to delivery

Maternal COVID-19 symptoms peripartum

Indication for delivery

Route of delivery

Birth outcome

Neonatal course

Fetal/Infant COVID test results

MGH2

24

1

0

30

3

Intubated/Ventilated

Twins

NRFHT

Maternal respiratory status

CS

Livebirth X2

Both twins to NICU with complications of prematurity

Each twin

Negative X2

MGH3

25

1

0

33 + 4

PP day 5 negative

No symptoms

PPROM

VD

Livebirth

Benign

Negative X2

MGH4

33

3

0

40 + 1

7

Mild SOB, myalgias

Decreased fetal activity

NRFHT

CS

Livebirth

Benign

Negative X1

MGH8

33

3

2

37 + 4

0

No symptoms

Abruption, DIC required gravid Hysterectomy

CS

Livebirth

NICU for neonatal encephalopathy

Negative X1

MGH9

32

2

0

36

PP day 1

Anosmia, fever, chills, fatigue

Placental previa, vaginal bleeding, labor

CS

Livebirth

Benign

Positive at 24 and 48 h of life

MGH10

37

5

3

22

7

Fever, cough, head- ache

IUFD

VD

Stillbirth

Stillbirth

Not performed

MGH11

29

2

1

30 + 6

0 (H/O +test at 23 weeks GA then −test X2 but + on admission to LD)

Anosmia

Twins

PPROM/PTL

NRFHT

1 twin breech

CS

Livebirth X2

Both admitted to the NICU with respiratory complications related to prematurity

Each twin Negative X2

MGH12

32

2

1

38 + 5

3

No symptoms

Term labor

VD

Livebirth

Benign

Negative X1

MGH13

25

4

2

36 + 3

3

SOB, fever, cough, pneumonia on CXR

Maternal respiratory Status, NRFHT

CS

Livebirth

Benign

Negative X1

MGH14

22

1

0

41 + 1

0

No symptoms

Spontaneous labor

VD

Livebirth

Benign

Negative X1

BWH2

25

2

1

39 + 5

3

No symptoms

Spontaneous labor

VD

Livebirth

Benign

Negative X1

BWH4

26

2

1

37 + 2

2

Rhinorrhea, cough

Cholestasis

VD

Livebirth

Benign

Negative X1

BWH5

39

4

3

37 + 1

0

Fever, low oxygen saturation in labor

T2DM

CS

Livebirth

Macrosomia

Benign

Negative X1

BWH6

33

1

0

38 + 3

0

No symptoms

PIH, FGR

VD

Livebirth

Benign

Negative X1

BWH9

35

4

0

38 + 3

3

No symptoms

PET

CS

Livebirth

Benign

Negative X1

BIDMC1

36

3

0

37.2

8

DOE, cough

cHTN, GDM

CS

Livebirth

Benign

Not performed

BIDMC2

34

3

1

35.3

7

Respiratory distress on 4 L O2 then intubated immediately PP, hypoxemia, cough

Maternal respiratory status, breech

CS

Livebirth

NICU for hypoglycemia and prematurity

Negative X1

BIDMC3

28

2

1

31.6

9

Fever, “worsening respiratory symptoms” no supplemental O2, cough, malaise, myalgia, rash

Maternal respiratory status

CS

Livebirth

NICU for respiratory distress, rash, and prematurity

Negative X1

BIDMC4

42

2

0

29.3

1

Fever, no respiratory symptoms

Chronic abruptio, PPROM, decreased fetal activity

VD

Livebirth

NICU for respiratory distress and prematurity

Negative X1

BIDMC5

28

2

1

35.5

5

Respiratory difficulty on 2 L O2, cough, fever, hemoptysis, sore throat, myalgia

Maternal COVID symptoms, Breech

CS

Livebirth

Mild pulmonary immaturity

Negative X1

  1. cHTN chronic hypertension, CS cesarean section, CXR chest X-ray, DIC disseminated intravascular coagulation, DOE dyspnea on exertion, FGR fetal growth restriction, GDM gestational diabetes mellitus, H/O history of, HSV herpes simplex virus, IUFD intrauterine fetal demise, L liter, NRFHT nonreassuring fetal heart testing, PET preeclampsia, PIH pregnancy induced hypertension, PP post partum, PPROM preterm premature rupture of membranes, SOB shortness of breath, T2DM type 2 diabetes mellitus, VD vaginal delivery.