Fig. 1: Morphologic and immunophenotypic features of sarcoma-like mural nodules. | Modern Pathology

Fig. 1: Morphologic and immunophenotypic features of sarcoma-like mural nodules.

From: Mural nodules in mucinous ovarian tumors represent a morphologic spectrum of clonal neoplasms: a morphologic, immunohistochemical, and molecular analysis of 13 cases

Fig. 1

A sarcoma-like mural nodule (Case #11) is well-circumscribed (a, ×20), with a central hemorrhagic cyst (b, ×20) showing an aneurysmal bone cyst-like arrangement of osteoclast-like giant cells (c, ×100) and a mixed cell population (d, ×200). A second sarcoma-like mural nodule (#13) is well-circumscribed and protrudes into a cystic lumen (e, ×4). The shoulder of the nodule is lined by mucinous epithelium (f, ×100). The mixed cell population (g, ×200) shows strong-diffuse mutant-pattern p53 expression (h, ×200, p53 IHC) and rare cytokeratin-positive cells (i, ×200, AE1/AE3 IHC).

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