Fig. 2: Morphologic and immunophenotypic features of anaplastic carcinomatous nodules. | Modern Pathology

Fig. 2: Morphologic and immunophenotypic features of anaplastic carcinomatous nodules.

From: Mural nodules in mucinous ovarian tumors represent a morphologic spectrum of clonal neoplasms: a morphologic, immunohistochemical, and molecular analysis of 13 cases

Fig. 2

A anaplastic carcinomatous nodule (Case #3) shows mixed epithelioid and sarcomatoid (pleomorphic) morphology (a, ×200), patchy cytokeratin expression (b, ×200, AE1/AE3 IHC), and strong-diffuse mutant-pattern p53 expression (c, ×200, p53 IHC). Metaplastic bone formation is also seen (d, ×100). A second anaplastic carcinomatous nodule (Case #5) is well-circumscribed (e, ×40) and shows epithelioid morphology with only modest nuclear atypia and a brisk inflammatory infiltrate (f, ×200), strong-diffuse mutant-pattern p53 expression (g, ×200, p53 IHC) and MTAP loss (h, ×200, MTAP IHC). Strong membranous HER2 expression (i, ×200, HER2 IHC) is seen in the epithelium of the adjacent mucinous borderline tumor (left) but not in the anaplastic carcinomatous nodule (right). In one focus (j, ×100), the anaplastic carcinomatous component (right) merges with better differentiated gland-forming mucinous adenocarcinoma.

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