Fig. 3: Pathologic findings of peritoneal tumors harboring alternative fusions (FUS–CREM and EWSR1–ATF1 fusions). | Modern Pathology

Fig. 3: Pathologic findings of peritoneal tumors harboring alternative fusions (FUS–CREM and EWSR1–ATF1 fusions).

From: EWSR1/FUS–CREB fusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavities

Fig. 3: Pathologic findings of peritoneal tumors harboring alternative fusions (FUS–CREM and EWSR1–ATF1 fusions).

a–c (Case 3, 63/M) predominantly solid omental mass associated with an abundant lymphoid infiltrate, resembling an involved lymph node (a), which at higher power showed sheets of monomorphic epithelioid cells with eccentric round nuclei and somewhat rhabdoid appearance (b). Immunohistochemical stain for Cam5.2 cytokeratin showed diffuse positivity (c). d–f (Case 9, 62/M, peripancreatic) Cystic lesion associated with prominent lymphoid aggregates and focal hemorrhagic changes (d), which at higher power showed a mixture of epithelioid and spindle cells with mild to moderate nuclear atypia (e). Tumor showed diffuse positivity for ALK (f). g–i (Case 13, 36/F, rectovaginal pouch) A similar cystic and hemorrhagic lesion (g), which at high power was composed of epithelioid and rhabdoid cells with densely eosinophilic cytoplasm, and was diffusely positive for cytokeratins and ultrastructurally showed abundant intracytoplasmic tonofilaments but lacking mesothelial differentiation (i).

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