Table 1 Baseline characteristics of the study cohort according to squamous cell carcinoma and adenocarcinoma histology.

Age, years (median [IQR])

63[55.25–69.75]

62[55.75–68.25]

0.788^a

68[59–71]

Smoking status

n = 48 (%)

n = 49 (%)

0.193^b

n = 6 (%)

 Non-smoker

3(6.2)

9(18.4)

2(33.3)

 Ex-smoker

27(37.5)

22(44.9)

4(66.7)

 Active smoker

18(56.2)

18(36.7)

Macroscopic tumor bed, cm (median [IQR])

3.5[2.58–5.42]

3.5[2.38–4.20]

0.385^a

4[1.9–4.35]

Adjusted tumor size, cm (median [IQR])

1.24[0.06–2.76]

1.78[0.05–2.95]

0.832^a

0[0–3.16]

ypT-TNM8

n = 54 (%)

n = 56 (%)

0.805^a

n = 7 (%)

 ypT0

6(11.1)

5(8.9)

4(57.1)

 ypT1

14(25.9)

19(33.9)

 ypT2a

11(20.4)

9(16.1)

 ypT2b

3(5.6)

3(5.4)

1(14.3)

 ypT3

6(11.1)

13(23.2)

1(14.3)

 ypT4

14(25.9)

7(12.5)

1(14.3)

TNM8

n = 54 (%)

n = 56 (%)

0.557^a

n = 7 (%)

 No vital tumor

3(5.6)

3(5.4)

4(57.1)

 Stage I

10(18.5)

12(21.4)

 Stage II

14(25.9)

11(19.7)

 Stage III

26(48.1)

26(46.4)

3(42.9)

 Stage IV

1(1.9)

4(7.1)

Regression

n = 54 (%)

n = 56 (%)

0.460^a

n = 7 (%)

 pCR

3(5.6)

4(7.1)

4(57.1)

 <1%

9(16.7)

9(16.1)

 1–10%

9(16.7)

6(10.7)

 11–49%

9(16.7)

6(10.7)

1(14.3)

 ≥50%

24(44.3)

31(55.4)

2(28.6)

PRSC

n = 54 (%)

n = 56 (%)

0.332^a

n = 7 (%)

 Low risk

23(42.6)

21(37.5)

4(57.1)

 Intermediate risk

14(25.9)

25(44.6)

1(14.3)

 High risk

17(31.5)

10(17.9)

2(28.6)

Neoadjuvant chemotherapy

n = 53 (%)

n = 55 (%)

0.551^b

n = 7 (%)

 Cisplatin + docetaxel

31(58.5)

31(56.4)

6(85.7)

 Carboplatin + paclitaxel

3(5.7)

2(3.6)

 Cisplatin + pemetrexed

6(11.3)

7(12.7)

 Cisplatin + gemcitabin

6(11.3)

3(5.5)

 Cisplatin + vinorelbin

2(3.8)

7(12.7)

1(14.3)

 Cisplatin + etoposid

1(1.8)

 Other

5(9.4)

4(7.3)

Neoadjuvant radiotherapy

n = 50 (%)

n = 54 (%)

0.689^b

n = 7 (%)

 No

38(76)

38(70.4)

4(57.1)

 Yes

12(24)

16(29.6)

3(42.9)

Surgical procedure

n = 54 (%)

n = 56 (%)

0.001^b

n = 7 (%)

 Lobectomy

23(42.6)

42(75)

4(57.1)

 Bilobectomy

4(7.4)

1(1.8)

 Pneumonectomy

27(50)

13(23.2)

3(42.9)

R

n = 53 (%)

n = 55 (%)

0.031^b

n = 7 (%)

 R0

41(77.4)

51(92.7)

7(100)

 R1

12(22.6)

4(7.3)