Fig. 3: Post-neoadjuvant chemotherapy breast excision with no residual invasive carcinoma and persistent atypical microglandular adenosis (AMGA) and carcinoma involving microglandular adenosis (C-MGA). | Modern Pathology

Fig. 3: Post-neoadjuvant chemotherapy breast excision with no residual invasive carcinoma and persistent atypical microglandular adenosis (AMGA) and carcinoma involving microglandular adenosis (C-MGA).

From: Morphologic and immunohistochemical features of carcinoma involving microglandular adenosis of the breast following neoadjuvant chemotherapy

Fig. 3

A Low power view of tissue section showing biopsy site changes in upper left, treatment related changes without residual invasive carcinoma in center, and persistent AMGA/C-MGA in lower right. Inset shows higher power of AMGA/C-MGA exhibiting single cell pattern (H&E, 20X; inset H&E, 50X); B Absence of myoepithelial cells around AMGA/C-MGA (ADH5, 100X); C Residual AMGA/C-MGA with positive nuclear staining with S-100 protein (100X); Preservation of basement membrane surrounding AMGA/C-MGA (D collagen IV, 100X; E laminin, 100X).

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