Fig. 4: Post-neoadjuvant chemotherapy breast excision with residual invasive carcinoma and persistent atypical microglandular adenosis (AMGA) and carcinoma involving microglandular adenosis (C-MGA). | Modern Pathology

Fig. 4: Post-neoadjuvant chemotherapy breast excision with residual invasive carcinoma and persistent atypical microglandular adenosis (AMGA) and carcinoma involving microglandular adenosis (C-MGA).

From: Morphologic and immunohistochemical features of carcinoma involving microglandular adenosis of the breast following neoadjuvant chemotherapy

Fig. 4

Residual poorly differentiated invasive carcinoma with surrounding inflammatory infiltrate and stromal reactive changes and extensive residual AMGA/C-MGA present as small glands, interconnected chains and single cells with an infiltrative pattern (A H&E, 10X; B H&E, 100X; C H&E, 50X); D Poorly differentiated invasive carcinoma with desmoplastic stromal reaction (H&E, 50X); Absence of basement membrane surrounding residual invasive carcinoma (E collagen IV, 50X; F laminin, 50X); G AMGA/C-MGA with infiltrative single cell pattern without stromal reactive changes (H&E, 100X); Preservation of basement membrane around AMGA/C-MGA (H collagen IV, 50X; I laminin, 50X); Absence of myoepithelial cells around AMGA/C-MGA (J calponin, 50X; K p63, 50X); L AMGA/C-MGA showing positive nuclear staining with S-100 protein (50X).

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