Table 2 Pathologic features of study cohort.

Case	Original reported biopsy diagnosis	Biopsy morphologic review				Post-NAC excision morphologic review				Immunohistochemical findings in MGA, AMGA, and/or C-MGA
Case	Original reported biopsy diagnosis	TNBC	DCIS	AMGA	C-MGA	TNBC	DCIS	AMGA	C-MGA	S-100	Laminin	Collagen IV	Calponin	p63
1	TNBC and DCIS	No	No	Yes^a	Yes	No	No	Yes	Yes	+	+	+	ND	ND
2	TNBC	No	No	Yes	Yes	No	No	Yes	Yes	+	+	+	−	−
3	TNBC	No	No	No	Yes	No	Yes	No	Yes	+	+	+	−	−
4	TNBC with metaplastic features in association with MGA and AMGA	Yes	No	Yes^a	No	Yes (0.2 cm)	No	Yes	No	+	+	+	ND	ND
5	TNBC with metaplastic features and DCIS	Yes	No	Yes^a	No	No	No	No	Yes	+	+	+	ND	ND
6	TNBC and DCIS	Yes	Yes	No^b	No^b	Yes (6.5 cm)	No	No	Yes	+	ND	ND	ND	ND
7	TNBC	Yes	Yes	No^b	No^b	No	No	Yes^a	No	+	ND	ND	ND	ND
8	TNBC and DCIS	Yes	Yes	No^b	No^b	No	Yes	Yes	No	+	+	+	−	−
9	TNBC with focal metaplastic features	Yes	No	Yes	Yes	No	No	Yes	No	+	ND	+	ND	ND
10	TNBC	Yes	No	Yes	No	Yes (3 cm)	No	Yes	No	+	+	+	−	−
11^c	TNBC	Yes	No	Yes	No	Yes (3 cm)	No	Yes	No	ND	ND	ND	ND	ND
12^c	TNBC	Yes	No	Yes	Yes	No	No	No	Yes	+	+	+	−	−

^aMGA also identified.
^bConsultation slides (AMGA and/or C-MGA not present in submitted material).
^cIn-house biopsy specimens.
TNBC triple negative invasive breast carcinoma, DCIS ductal carcinoma in situ, AMGA atypical microglandular adenosis, MGA microglandular adenosis, C-MGA carcinoma involving microglandular adenosis, NAC neoadjuvant chemotherapy, ND not done.

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