Table 2 Summary of immunohistochemical and molecular findings in cohort of patients with hybrid schwannoma–perineurioma.

Case	Immunohistochemistry							RNA-seq	FISH
	S100	SOX10	CD34	EMA	Claudin-1	GLUT-1	H3K27me3
Index	D+	D+	D+	M+	M+	M+	Intact	CHD7-VGLL3	+/+
2	D+	D+	M+	M+	N/A	N/A	Intact	CHD7-VGLL3	N/A
3	D+	D+	D+	M+	M+	M+	N/A	CHD7-VGLL3	N/A
4	D+	N/A	M+	M+	Multifocal	N/A	N/A	CHD7-VGLL3	N/A
5	D+	N/A	M+	D+	N/A	N/A	N/A	CHD7-VGLL3	N/A
6	D+	N/A	D+	D+	N/A	N/A	N/A	CHD7-VGLL3	N/A
7	M+	N/A	N/A	M+	N/A	N/A	N/A	CHD7-VGLL3	N/A
8	D+	D+	N/A	N/A	N/A	N/A	N/A	CHD7-VGLL3*	+/+
9	D+	D+	M+	N/A	N/A	N/A	Intact	CHD7-VGLL3*	+/+
10	D+	D+	D+	M+	N/A	M+	Intact	CHD7-VGLL3*	+/+
11	D+	D+	D+	F+	D+	F+	N/A	CHD9-VGLL3	N/A
12	M+	N/A	D+	D+	N/A	N/A	N/A	CHD9-VGLL3	N/A
13	M+	M+	D+	M+	N/A	N/A	Intact	MAMLD1-VGLL3	N/A
14	D+	D+	N/A	–	N/A	N/A	N/A	MAMLD1-VGLL3*	N/A/+
15	M+	M+	M+	M+	M+	M+	N/A	DST-BRAF	+/+
16	D+	D+	–	M+	M+	–	N/A	SQSTM1-CDX1	N/A
17	M+	N/A	M+	M+	M+	N/A	N/A	Negative	−/−
18	D+	N/A	N/A	M+	M+	N/A	N/A	Negative	−/−

*RNA-Seq performed using Archer platform (all other cases Illumina TruSight RNA Fusion platform).
EMA epithelial membrane antigen, FISH fluorescence in situ hybridization, N/A not assessed, RNA-Seq RNA sequencing, Quantification of immunohistochemistry: D+ diffusely positive, F+ focal positivity, M+ multifocal, − negative.

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