Fig. 2: TRIM63 expression in TFE3 translocation RCC. | Modern Pathology

Fig. 2: TRIM63 expression in TFE3 translocation RCC.

From: TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma

Fig. 2

A TFE3 translocation RCC showing typical alveolar to nested growth pattern and clear to eosinophilic cells with voluminous cytoplasm, high-grade nuclei, and psammomatous calcification (H&E); inset demonstrated a TFE3 gene rearrangement by dual-color, break-apart FISH. B TRIM63 overexpression in TFE3 translocation RCC by RNA-ISH. TRIM63 signals were enriched in nuclei and also observed in cytoplasm. C, D The absence of TRIM63 expression in renal cortex and medulla, respectively; inset: H&E. Scale bars = 100 μm.

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