Fig. 3: Diagrammatic representation of tumors with EWSR1/FUS-NACC1 fusions. | Modern Pathology

Fig. 3: Diagrammatic representation of tumors with EWSR1/FUS-NACC1 fusions.

From: Unclassified low grade spindle cell sarcoma with storiform pattern characterized by recurrent novel EWSR1/FUS-NACC1 fusions

Fig. 3

A Upper panel summarizes the chromosomal locations of EWSR1 on 22q12.2, FUS on 16p11.2 and NACC1 on 19p13.2. Red vertical lines depict the genomic break, while the orange and green arrows reveal the direction of transcription of each gene partner. B Lower panel depicts the two variant fusions, in which NACC1 exon 2 is fused either with exon 7 of EWSR1 or exon 6 of FUS. The protein domains of each gene as well as the predicted domains preserved in the fusion oncoprotein are also illustrated.

Back to article page