Table 1 Clinical features of embryonal rhabdomyosarcomas of the uterine corpus.

From: Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations

Case number

Age (years)

Presentation

Size (cm)

Extrauterine disease

Adjuvant therapy

Recurrences

Follow-up

1a

47

Menorrhagia

8.5

-

Whole pelvic radiation, vaginal cuff boost, chemotherapy

Omentum, 5 months

DOD, 11 months

2a

45

Pelvic pain, vaginal bleeding

8.2

Omentum, peritoneum, anterior abdominal wall, adnexa, left pelvic sidewall, bladder peritoneum, sigmoid implant, cul-de-sac, small bowel implant

Chemotherapy

Progressive disease (subtotal resection)

DOD, 21 months

3

27

Vaginal bleeding

4

-

N/A

N/A

N/A

4a

52

Postmenopausal bleeding

D&C

-

-

-

NED, 11 months

5

70

Postmenopausal bleeding

10

-

Declined

Peritoneum, sigmoid colon, 4 months

DOD, 6 months

6a

30

Abnormal uterine bleeding, “delivering” fibroid

5

-

Chemotherapy

-

NED, 13 months

7a

28

Intermenstrual bleeding

5.6

-

Chemotherapy

-

NED, 97 months

8

59

Thickened endometrial stripe

10

-

-

-

DOC, 15 months

9

69

Postmenopausal bleeding

10.5

Left adnexa

N/A

N/A

DOD, 15 months

10a

60

N/A

9

-

-

-

NED, 52 months

11a

40

Abnormal uterine bleeding

4

-

N/A

N/A

N/A

12a

51

N/A

10

-

N/A

-

NED, 57 months

13

58

Postmenopausal bleeding

15

-

Chemotherapy

-

NED, 8 months

14

68

Postmenopausal bleeding

D&C

-

Chemotherapy

-

NED, 8 months

15a

53

Polyp

7.8

-

N/A

N/A

NED, 56 months

16a

28

Vaginal bleeding, prolapsed “fibroid”

4.5

-

N/A

N/A

N/A

17a

49

Abnormal uterine bleeding

D&C

-

Chemotherapy

Recent

Recent

18a

62

Postmenopausal bleeding

11.5

-

N/A

Recent

Recent

19a

64

“Cervical” mass

12.2

-

Chemotherapy

Recent

Recent

20

73

Irregular vaginal bleeding

10

-

N/A

-

NED, 28 months

21a

50

Vaginal bleeding, pelvic mass

8.1

-

Chemotherapy

Recent

Recent

  1. - = none.
  2. DOD dead of disease, NED no evidence of disease, D&C dilation and curettage, DOC dead from other causes, N/A not available.
  3. aDICER1 mutation.