Fig. 2: Focal trophoblastic damage.
From: Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise
A In this grossly normal-looking placenta few small foci of intervillous space collapse were found as the two here depicted. Inset is shown at a higher magnification in (B) (H&E, original magnification 10x). B Intervillous space collapse and trophoblastic necrosis looks quite similar to more extensive lesions depicted in Fig. 1 (original magnification, 20X). C Immunohistochemical staining for SARS-CoV-2 nucleoprotein shows staining in the injured villi but also in the surrounding normal-looking villi (original magnification 10X). D In situ hybridization with the RNAscope probe replicates the image of immunohistochemistry (original magnification 10x).
