Fig. 1: Morphological findings of synovial sarcomas with EWSR1-SSX1 fusions (cases 1–3). | Modern Pathology

Fig. 1: Morphological findings of synovial sarcomas with EWSR1-SSX1 fusions (cases 1–3).

From: Identification of novel SSX1 fusions in synovial sarcoma

Fig. 1: Morphological findings of synovial sarcomas with EWSR1-SSX1 fusions (cases 1–3).The alternative text for this image may have been generated using AI.

A–C Case 1 showed monophasic histology composed of swirling fascicles of uniform spindle cells (A, B). A poorly differentiated round cell component was focally present (C). D–F Case 2 showed papillary and glandular architecture (D). The tumor was biphasic, including fascicles of uniform spindle cells (E) and complex glandular formations of epithelial cells (F). G–I Case 3 displayed long fascicular (G) to whorled (H, necrosis is present in the bottom) spindle cell proliferation. The monomorphic tumor cells harbored a high nuclear/cytoplasmic ratio (I).

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