Fig. 6: DNA methylation-based unsupervised clustering.
From: Identification of novel SSX1 fusions in synovial sarcoma
The reference cohort (n = 1077) and our synovial sarcoma samples (n = 4; one control with SS18-SSX1, case 1 with EWSR1-SSX1, case 4 with MN1-SSX1, and case 5 with SS18L1-SSX1) were plotted using t-distributed stochastic neighbor embedding (t-SNE) dimensionality reduction. Our synovial sarcomas are indicated as red squares. Tumor name abbreviations and the color code of the 62 reference tumors and three control DNA methylation classes were the same as in Koelsche et al.19. Cases 1 and 5 are plotted within the synovial sarcoma cluster along with a positive control, while case 4 is plotted in the vicinity of Ewing sarcoma.
