Fig. 8: Proposed mechanism of FNH development: local hyperoxygenation and oxidative stress induce senescence in hepatocytes and cholangiocytes. | Modern Pathology

Fig. 8: Proposed mechanism of FNH development: local hyperoxygenation and oxidative stress induce senescence in hepatocytes and cholangiocytes.

From: Senescence markers in focal nodular hyperplasia of the liver: pathogenic considerations on the basis of immunohistochemical results

Fig. 8: Proposed mechanism of FNH development: local hyperoxygenation and oxidative stress induce senescence in hepatocytes and cholangiocytes.The alternative text for this image may have been generated using AI.

Transdifferentiation of hepatocytes to cholangiocytes may occur in combination with K7 expression and ductular metaplasia. The SASP responsible for fibrosis and inflammation while inhibiting apoptosis is leading to increased tissue volume observed in FNH, without necessitating increased proliferation.

Back to article page