Fig. 3: PI3K pathway and NOTCH pathway alterations in vulvovaginal squamous cell carcinomas. | Modern Pathology

Fig. 3: PI3K pathway and NOTCH pathway alterations in vulvovaginal squamous cell carcinomas.

From: Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma

Fig. 3

A Lollipop plot showing that all PIK3CA mutations in vulvovaginal squamous cell carcinomas in our cohort are activating mutations involving codons 542 and 545. B Oncoprint showing the NOTCH pathway alterations in vulvovaginal squamous cell carcinomas. C Interaction matrix plot showing the mutual exclusivity/co-occurrence of the common genomic alterations in vulvovaginal squamous cell carcinomas.

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