Fig. 4: Clonal evolution of HPV-independent vulvovaginal squamous cell carcinomas. | Modern Pathology

Fig. 4: Clonal evolution of HPV-independent vulvovaginal squamous cell carcinomas.

From: Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma

Fig. 4

A Alluvial graph showing the distribution of the three genomic alterations in vulvovaginal squamous cell carcinomas with the highest cancer cell fractions. All HPV-independent vulvovaginal squamous cell carcinomas have truncal alterations in a combination of TP53, TERT and NOTCH1 genes and any of these genes can have the highest cancer cell fraction in the tumors. B, C Phylogenetic reconstruction of the tumor evolution in two cases of metastatic/recurrent vulvovaginal squamous cell carcinomas.

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