Fig. 3: An ALK + ALCL case with a lymphohistiocytic pattern. | Modern Pathology

Fig. 3: An ALK + ALCL case with a lymphohistiocytic pattern.

From: Small cell/lymphohistiocytic morphology is associated with peripheral blood involvement, CD8 positivity and retained T-cell antigens, but not outcome in adults with ALK+ anaplastic large cell lymphoma

Fig. 3: An ALK + ALCL case with a lymphohistiocytic pattern.

A At low magnification (×40), the nodal architecture is mostly effaced by a diffuse lymphohistiocytic infiltrate. B At high magnification (×400), the infiltrate is composed of scattered small to medium-size lymphoma cells (red arrows) in a background of abundant histiocytes. C CD68 highlights numerous histiocytes (×40). The lymphoma cells are positive for CD30 (D; ×40), ALK (E, ×40; insert, ×400, nuclear and cytoplasmic staining) and CD3 (F, weak, red arrows; ×400). The reactive T cells show strong CD3 positivity (F, black arrows). A, B Hematoxylin-eosin stain. C–F Immunohistochemistry.

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