Fig. 1: Peripheral blood and bone marrow morphologic features of MDS/MPN-U with and without isolated i(17q). | Modern Pathology

Fig. 1: Peripheral blood and bone marrow morphologic features of MDS/MPN-U with and without isolated i(17q).

From: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Fig. 1

Top panel: representative images of typical BM morphological features of MDS/MPN-U with i(17q) [top panel] showing frequent pseudo-Pelger–Hüet neutrophils on bone marrow aspirate smear (A) and peripheral blood (B) smears with frequent dysplastic small hypolobated megakaryocytes (C, biopsy; inset: aspirate smear). Bottom panel: in contrast, cases of MDS/MPN-U without isolated i(17q) showed dysgranulopoiesis of all types such as hypogranulation of cytoplasm and neutrophilic nuclear hyperlobulation on bone marrow aspirate smear (D) and peripheral blood (E) smears. Megakaryocytic dysplasia was less frequent (F).

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