Fig. 2: Mutational landscape. | Modern Pathology

Fig. 2: Mutational landscape.

From: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Fig. 2

Cases of MDS/MPN-U with isolated i(17q) show significantly higher frequency of mutations in SETBP1 and SRSF2 compared to cases of MDS/MPN-U without i(17q). There were no significant differences in mutational frequencies in other genes such as ASXL1 and TET2. TP53 mutations were rare. Cases of MDS/MPN-U with clonal mutations in one of the MPN-associated genes that included JAK2, CALR, and MPL were excluded.

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