Fig. 2: A representative case of MGCTB with loss of H3.3 G34W expression and heterozygous loss of an H3F3A allele (Case 5). | Modern Pathology

Fig. 2: A representative case of MGCTB with loss of H3.3 G34W expression and heterozygous loss of an H3F3A allele (Case 5).

From: Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation

Fig. 2

a Atypical spindle tumor cells proliferate in (a) fascicular pattern. b The sarcomatous cells are negative for H3.3 G34W immunohistochemistry. c H3F3A mutation is not detected by Sanger sequencing. d Heterozygous loss of H3F3A is revealed by FISH. In most individual tumor cells, one red signal of H3F3A and two green signals are observed.

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