Fig. 2: Copy number variants (CNVs) in gastric amphicrine carcinomas. | Modern Pathology

Fig. 2: Copy number variants (CNVs) in gastric amphicrine carcinomas.

From: Genetic alterations in gastric amphicrine carcinomas and comparison with gastric mixed neuroendocrine-non-neuroendocrine neoplasms

Fig. 2

a An overview of CNVs in the eight gastric amphicrine carcinomas based on the results of an OncoScan CNV Assay. The chromosomes (1–22, X, and Y) are arranged in order. For each chromosome, the CNVs in eight cases are shown on the right (from left to right: case 1 to case 8). Blue bars indicate copy number gains, and red bars indicate copy number losses. b A typical case of gastric amphicrine carcinoma displaying gain of 20q13.12-q13.2 (red arrow, MYT1, NTSR1, and ZBTB46 are localized in this region) discerned in the whole genome view. c qPCR validation of MYT1, NTSR1, and ZBTB46 expression in eight gastric amphicrine carcinomas. The copy numbers of MYT1, NTSR1, and ZBTB46 were significantly higher in carcinomas than in normal tissue. d Immunohistochemistry staining (200×) showed diffuse positive signals for MYT1, NTSR1, and ZBTB46 in tumor cells, but no signal was observed in normal mucosa.

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