Table 2 The univariable and multivariable analysis of prognostic factors including new grading system and clinicopathologic characteristics.

From: Prognostic and predictive value of the newly proposed grading system of invasive pulmonary adenocarcinoma in Chinese patients: a retrospective multicohort study

Prognostic factors

Recurrence-free survival

Overall survival

Univariable analysis

Multivariable analysis

Univariable analysis

Multivariable analysis

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

New Grading system

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 Grade 1 vs Grade 3

0.113 (0.046–0.277)

<0.001

0.165 (0.067–0.409)

<0.001

0.099 (0.031–0.313)

<0.001

0.134 (0.042–0.428)

0.001

 Grade 2 vs Grade 3

0.429 (0.316–0.583)

<0.001

0.526 (0.383–0.722)

<0.001

0.360 (0.244–0.531)

<0.001

0.428 (0.287–0.639)

<0.001

Age (≥65)

1.414 (1.046–1.912)

0.024

1.331 (0.983–1.801)

0.064

1.764 (1.229–2.530)

0.002

1.710 (1.191–2.454)

0.004

Sex (Male)

1.361 (1.019–1.818)

0.037

  

1.487 (1.041–2.124)

0.029

  

Smoking history (Smoker)

1.062 (0.758–1.486)

0.728

  

1.209 (0.811–1.804)

0.352

  

Surgery strategy (Sublobar)

1.066 (0.579–1.961)

0.837

  

0.757 (0.396–1.446)

0.757

  

T stage

 

0.001

 

0.064

 

0.007

  

 T1a vs T2a

0.219 (0.070–0.690)

0.009

0.381 (0.120–1.217)

0.103

0.217 (0.053–0.884)

0.033

  

 T1b vs T2a

0.491 (0.327–0.738)

0.001

0.764 (0.491–1.187)

0.231

0.478 (0.290–0.790)

0.004

  

 T1c vs T2a

0.951 (0.654–1.382)

0.791

1.296 (0.861–1.949)

0.213

0.858 (0.535–1.377)

0.526

  

Pathological stage (IB)

1.626 (1.205–2.194)

0.001

  

1.733 (1.195–2.514)

0.004

  

Predominant pattern

 

<0.001

   

<0.001

  

 Lepidic vs CG

0.112 (0.044–0.283)

<0.001

  

0.093 (0.028–0.305)

<0.001

  

 Acinar vs CG

0.565 (0.389–0.820)

0.003

  

0.456 (0.290–0.717)

0.001

  

 Papillary vs CG

0.389 (0.234–0.649)

<0.001

  

0.331 (0.175–0.624)

0.001

  

 MP vs CG

1.514 (0.679–3.375)

0.311

  

1.421 (0.551–3.664)

0.468

  

 Solid vs CG

1.500 (0.906–3.375)

0.115

  

1.572 (0.893–2.769)

0.117

  

Visceral pleural invasion (Presence)

2.823 (2.043–3.901)

<0.001

1.873 (1.285–2.731)

0.001

2.762 (1.865–4.091)

<0.001

1.802 (1.202–2.701)

0.004

Lymphovascular invasion (Presence)

2.611 (1.820–3.745)

<0.001

1.869 (1.296–2.695)

0.001

2.800 (1.826–4.294)

<0.001

2.004 (1.300–3.090)

0.002

Pathological tumor size

1.671 (1.410–1.980)

<0.001

  

1.744 (1.418–2.145)

<0.001

  
  1. HR hazard ratio, CI confidence interval, CG complex glandular, MP micropapillary.
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