Table 3 The clinicopathologic characteristics of patients with pathologic stage IB IPA with and without adjuvant chemotherapy.
Characteristic | Overall group (n = 490) | Observation (n = 192) | ACT (n = 298) | p value |
|---|---|---|---|---|
Age, years | <0.001 | |||
<65 | 334 (68.2) | 113 (58.9) | 221 (74.2) | |
≥65 | 156 (31.8) | 79 (41.1) | 77 (25.8) | |
Sex | 0.754 | |||
Female | 285 (58.2) | 110 (57.3) | 175 (58.7) | |
Male | 205 (41.8) | 82 (42.7) | 123 (41.3) | |
Smoking history | <0.001 | |||
Non-smoker | 386 (78.8) | 126 (65.6) | 260 (87.2) | |
Smoker | 104 (21.2) | 66 (34.4) | 38 (12.8) | |
Surgery strategy | 0.418 | |||
Sublobar resection | 21 (4.3) | 10 (5.2) | 11 (3.7) | |
Lobectomy | 469 (95.7) | 182 (94.8) | 287 (96.3) | |
Grading by ADC classification | 0.001 | |||
Grade 1 | 36 (7.3) | 25 (13.0) | 11 (3.7) | |
Grade 2 | 407 (83.1) | 151 (78.6) | 256 (85.9) | |
Grade 3 | 47 (9.6) | 16 (8.3) | 31 (10.4) | |
New grading system | <0.001 | |||
Grade 1 | 36 (7.3) | 25 (13.0) | 11 (3.7) | |
Grade 2 | 236 (48.2) | 103 (53.6) | 103 (44.6) | |
Grade 3 | 218 (44.5) | 64 (33.3) | 120 (51.7) | |
Predominant subtype | < 0.001 | |||
Lepidic | 35 (7.1) | 24 (12.5) | 11 (3.7) | |
Acinar | 232 (47.3) | 82 (42.7) | 150 (50.3) | |
Papillary | 109 (22.2) | 49 (25.5) | 60 (20.1) | |
Micropapillary | 12 (3.4) | 6 (3.1) | 6 (2.0) | |
Solid | 36 (7.3) | 10 (5.2) | 26 (8.7) | |
Complex glands | 66 (13.5) | 21 (10.9) | 45 (15.1) | |
Visceral pleural invasion | 0.025 | |||
Absence | 358 (73.1) | 151 (78.6) | 207 (69.5) | |
Presence | 132 (26.9) | 41 (21.4) | 91 (30.5) | |
Lymphovascular invasion | 0.034 | |||
Absence | 430 (87.8) | 176 (91.7) | 254 (85.2) | |
Presence | 60 (12.2) | 16 (8.3) | 44 (14.8) | |
Pathological tumor size, mm, mean ± SD | 24.8 ± 8.7 | 24.3 ± 8.7 | 25.1 ± 8.6 | 0.374 |
