Fig. 1: Histopathological findings in an MDPT with a satellite and locoregional metastases (Case 14). | Modern Pathology

Fig. 1: Histopathological findings in an MDPT with a satellite and locoregional metastases (Case 14).

From: Towards diagnostic criteria for malignant deep penetrating melanocytic tumors using single nucleotide polymorphism array and next-generation sequencing

Fig. 1

A Skin excision of the back of a 74-year-old man with a strongly pigmented deep penetrating, asymmetrical lesion with epidermal effacement. B Detail showing the epitheloid, enlarged, polymorphic melanocytes with prominent nucleoli and nuclear variation. A mitosis is easily identified (white arrow). C The lesion shows strong nuclear PRAME expression. D Lymph node metastatic deposit of 8.6 mm. E In a different section, a satellite is clearly visibly (white arrow). F p16 expression is completely lost in the lesional cells. G β-catenin staining shows membranous and partly cytoplasmic and nuclear staining. H Detail of metastatic deposit with tumor cells. I Detail showing the satellite of the lesion. In addition, this MDPT had severe inflammation with the presence of plasma cells, NGS showed a CTNNB1S33P and KITL576P mutation (the TERT-p region was not interpretable), and SNP array identified 3 CNVs and one copy-neutral loss-of-heterozygosity. BAP1 and PRKAR1A IHC were not aberrant (not shown).

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