Fig. 4: Microscopic honeycomb change in UIP (gross-microscopic correlation).
From: Usual interstitial pneumonia (UIP): a clinically significant pathologic diagnosis
Explanted lung from a patient with a clinical diagnosis of IPF. The macroscopic image shown in (A) corresponds to (B) (microscopic); (C) (gross) corresponds to (D) (microscopic). A Subpleural lung (purple box indicates exact area shown in (B)). Short black arrow: pleura. Long black arrow: honeycombing visible grossly. Black arrowhead: fibrosis without grossly visible honeycombing. B Microscopy provides greater detail than appreciable grossly. Short black arrow: pleura. Long black arrow: honeycomb change. Black arrowhead: microscopic honeycombing. C Another area from same lung, more central (closer to hilum; purple box indicates exact section shown in (D)). Arrowhead: pulmonary artery. Long arrow: Bronchial cartilage. Short arrows: This area appears fibrotic grossly but does not show honeycombing. (D) Microscopic correlate of (C). Arrowhead: pulmonary artery. Long arrow: Bronchial cartilage. Short arrows: Extensive microscopic honeycombing is present. Images courtesy of Dr. Frido Bruehl.
