Fig. 5: DNA content histograms of NDBE and HGD. | Modern Pathology

Fig. 5: DNA content histograms of NDBE and HGD.

From: Utility of ancillary studies in the diagnosis and risk assessment of Barrett’s esophagus and dysplasia

Fig. 5

A, B NDBE is characterized by the presence of intestinal metaplasia, but there is no dysplasia. The DNA histogram shows a normal diploid population (green). C, D HGD is characterized by severe cytologic atypia with enlarged, hyperchromatic, rounder nuclei. The DNA histogram demonstrates a discrete aneuploid peak (red) that is bimodally distinguishable from the normal diploid peak (green). E, F Another example of HGD shows atypical glands lined by highly pleomorphic cells with enlarged nuclei. There is an elevated 4 N fraction greater than 6% (with DNA index of 1.9–2.1) in the DNA histogram. No distinct aneuploid population is present.

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