Fig. 1: Grading of LMO2 immunohistochemistry staining in T-LL. | Modern Pathology

Fig. 1: Grading of LMO2 immunohistochemistry staining in T-LL.

From: LMO2 expression is frequent in T-lymphoblastic leukemia and correlates with survival, regardless of T-cell stage

Fig. 1

In normal tonsil, LMO2 immunohistochemistry staining shows strong nuclear positivity in A germinal center B cells (IHC, x40) and (B) endothelial cells (IHC, x100), while LMO2 is negative in B surrounding normal T-cells (IHC, x100) (C). An example of T lymphoblastic leukemia (T-LL) extensively involving bone marrow (Hematoxylin & Eosin stain, x100). D T-LL with negative LMO2 expression. In this example, lymphoblasts are negative for LMO2 while scattered endothelial cells (arrow), as internal positive control, are positive for LMO2 (IHC, x100). E T -LL with weak (1+) and variable expression of LMO2. F T-LL with diffuse and strong (2+) expression of LMO2 in >90% of lymphoblasts.

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