Fig. 1: Histologic examples of cases that changed grade from the Lerner system compared to our system. | Modern Pathology

Fig. 1: Histologic examples of cases that changed grade from the Lerner system compared to our system.

From: Multi-institutional development and validation of a novel histologic grading system for colonic graft-versus-host disease

Fig. 1: Histologic examples of cases that changed grade from the Lerner system compared to our system.The alternative text for this image may have been generated using AI.

A case with abundant crypt apoptosis and no crypt dropout. According to the Lerner system this would be called grade 1 but would be classified as grade 2 (still low grade) by our system (A). A case with abundant crypt apoptosis and single crypt dropout (arrowhead). According to the Lerner system this would be grade 2 but would be upgraded to grade 3 by our system (B). A case with contiguous crypt dropout and rare crypt apoptosis (arrowhead). According to the Lerner system this would be grade 3 but would be downgraded to grade 2 by our system (C). A case with extensive ulceration and near-total loss of crypts. Crypt apoptosis is noted in the remaining crypts (arrow) but the overall count is low due to paucity of remaining crypts. According to the Lerner system this would be grade 4 but qualifies as grade 3 by our system (D).

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