Table 2 Molecular findings.
Case | RNA-Seq | DNA NGS | Activated Pathways |
|---|---|---|---|
1 | FN1::NRG1 | NA | MAPK, PI3K |
2 | PRKAR1A::MET | NA | MAPK, PI3K |
3 | ETV6::NTRK3 | NA | MAPK, PI3K |
4 | DNAJB1::PRKACA | − | cAMP |
5 | − | CTNNB1 p.S33F | Wnt |
6 | − | CTNNB1 p.S33F | Wnt |
7 | Failed | BRAF p.V600E, AKT1 p.E17K | MAPK, PI3K |
8 | − | BRAF p.V600E, AKT1 p.E17K | MAPK, PI3K |
9 | − | − | NA |
10 | − | − | NA |
11 | − | CDKN2A homozygous loss | Cell cycle |
12 | − | TP53 p.K132M | Cell cycle |
13 | − | NF1 p.S1262fs and c.888 + 1 G > T | MAPK |
14 | − | CUL3 p.V427fs | Proteolysis |
15 | − | RAF1 amplification | MAPK |
16 | − | − | NA |
17 | Failed | − | NA |
18 | Failed | Failed | NA |
