Fig. 2: Copy number-based tumor purity calculation compared to driver mutation allele fraction. | Modern Pathology

Fig. 2: Copy number-based tumor purity calculation compared to driver mutation allele fraction.

From: Deriving tumor purity from cancer next generation sequencing data: applications for quantitative ERBB2 (HER2) copy number analysis and germline inference of BRCA1 and BRCA2 mutations

Fig. 2: Copy number-based tumor purity calculation compared to driver mutation allele fraction.

A Calculated tumor purity in colorectal cancers based on copy number changes (X-axis) versus RAS driver mutation allele fraction (Y-axis) shows linear correlation (R2 = 0.79). B Calculated tumor purity (X-axis) versus histologic estimation (Y-axis) shows poor correlation (R2 = 0.01).

Back to article page