Fig. 2: GNAS mutational analysis in one case with overlapping clinical characteristics of FD and DSOM. | Modern Pathology

Fig. 2: GNAS mutational analysis in one case with overlapping clinical characteristics of FD and DSOM.

From: GNAS mutation analysis assists in differentiating chronic diffuse sclerosing osteomyelitis from fibrous dysplasia in the jaw

Fig. 2

A, B Clinical image of the patient. C Three-dimensional reconstruction of the CT images showed swelling of the left mandible. D, E CT and panoramic radiograph revealed an expansion of ramus and corpus of the left mandible with a “ground-glass” appearance. Cystic change without a sclerotic margin could be seen in the body of the mandible. F The sign of subperiosteal bone formation on the left mandible. G Histologic features of the lesion: the low-power view (HE, 40×) showing small, round and disconnected bones lying within a fibrous stroma. H Part of these bones were rimmed with osteoblasts in the high-power view (arrow; HE, 400×). I The sequence of polymerase chain reaction (PCR)-amplified product showed a mutation at the Arg201 codon (arrow), CAG > CAT (p.Q227H).

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