Fig. 6: Gross and histologic features of type 1/3 CPAMs. | Modern Pathology

Fig. 6: Gross and histologic features of type 1/3 CPAMs.

From: Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features

Fig. 6

Three examples are shown. Grossly, these lesions consist of solid appearing parenchyma with admixed larger cystic spaces (A–C). The low power appearance is heterogenous, with more solid appearing areas intermixed with large cysts and relatively normal appearing alveolar type spaces (D–F). Larger cysts are lined by ciliated columnar epithelium, similar to a type 1, while more solid appearing areas demonstrate increased mesenchyme, similar to a type 3 (G–I).

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