Fig. 5: PTEN and ARID1A expression patterns in adenosarcomas. | Modern Pathology

Fig. 5: PTEN and ARID1A expression patterns in adenosarcomas.

From: Mullerian adenosarcoma: clinicopathologic and molecular characterization highlighting recurrent BAP1 loss and distinctive features of high-grade tumors

Fig. 5: PTEN and ARID1A expression patterns in adenosarcomas.

A, B Immunohistochemical analysis of tumors harboring PTEN mutations demonstrates loss of PTEN expression in the neoplastic mesenchymal component in MA22 (A), but confined to the proliferative glands in MA01 (B). C In MA26, with ARID1A mutation, loss of expression is confined to endometrial glands exhibiting atypical hyperplasia. D–F MA10 with MLH1 homozygous deletion, showing loss of MLH1 (E) and PMS2 (F) expression in the mesenchymal component.

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