Table 1 Gene list overlaps

From: An integrated analysis of genes and functional pathways for aggression in human and rodent models

Gene overlap

GWAS_Adult

GWAS_Child

KO_Mice

Mice_Finland

Mice_Holland

Mice_USA

OMIM

Rat

(N/p-values)

(N = 175)

(N = 281)

(N = 89)

(N = 381)

(N = 271)

(N = 397)

(N = 85)

(N = 211)

GWAS_Child

6

       

(N = 281)

p=0.038

       

KO_Mice

1

4

      

(N = 89)

p = 0.544

p=0.037

      

Mice_Finland

1

6

6

     

(N = 381)

p = 0.269

p = 0.662

p=0.007

     

Mice_Holland

2

2

1

13

    

(N = 271)

p = 1

p = 0.597

p = 1

p=0.002

    

Mice_USA

3

11

4

11

12

   

(N = 397)

p = 1

p=0.029

p = 0.102

p = 0.193

p=0.013

   

OMIM

1

3

4

3

1

1

  

(N = 85)

p = 0.528

p = 0.118

p=0.001

p = 0.221

p = 1

p = 1

  

Rat

1

4

6

5

5

10

3

 

(N = 211)

p = 1

p = 0.546

p<0.0001

p = 0.606

p = 0.215

p=0.010

p = 0.061

 

GWAS_Contrl

1

1

2

1

4

2

1

2

(N = 172)

p = 1

p = 0.737

p = 0.179

p = 0.389

p = 0.301

p = 0.779

p = 0.522

p = 0.704

  1. The total number of genes in each lists and shared numbers of genes across different list is tabulated. Fisher’s exact test was used to evaluate the lists overlap based on ~22,000 total known genes for rodents and human. Significant overlaps (p < 0.05, uncorrected) are highlighted as bold