Fig. 5
d-cycloserine treatment normalizes abnormal aggression and blunted fear memory. a–c Effect of acute i.c.v. DCS infusion (cannula implanted in the lateral ventricle (LV), a) on abnormal aggressiveness (b, two-way ANOVA: treatment effect for vulnerable bites: F1,24 = 6.14, p = 0.023 and for submissive attacks: F1,24 = 6.46, p = 0.019, Bonferroni post hoc tests) and acoustic fear conditioning (c, right, MANOVA: interaction factor “genotype × treatment”: F1,24 = 4.69, p = 0.041) in wild-type (WT) and St8sia2−/− (KO) mice. d–f Effects of acute DCS intra-amygdala infusion (cannula implanted in the lateral amygdala, d) on abnormal aggressiveness (e, two-way ANOVA: interaction factor “treatment × genotype” for bites in vulnerable parts: F1,26 = 5.071, p = 0.039; treatment effect for submissive attacks: F1,26 = 5.41, p = 0.035, Bonferroni post hoc tests) and acoustic fear conditioning (f, right, MANOVA: interaction factor “genotype x treatment”: F1,20 = 3.59, p = 0.02) Results are given as mean ± SEM. *p < 0.05; **p < 0.01
