Table 2 List of candidate regions and genes selected based on the linkage analysis in each family

			Gene-set analysis
Family	LR selected	Genes with rare variants in WES	P_{self-contained}	P_competitive
P1	8:118608158–124649389	-----	0.2838	0.4512
	9:7754113–15568230	TYRP1, FREM1
	9:97466973–102213749	-----
	11:115218677–120365028	NXPE1,TMEM25, HYOU1, VPS11, ABCG4, CCDC153
	16:63079319–66386711	HSF4
	16:81159781–83154022	DYNLRB2, PKD1L2, PLCG2, OSGIN1, MBTPS1
P2	8:118608158–124649389	DEPTOR, ATAD2	0.0066	0.0042
	9:7754113–15568230	PTPRD, TYRP1, FREM1
	9:97466973–102213749	HSD17B3, AAED1, ANP32B^a, TBC1D2
	10:56177098–58789387	PCDH15
	10:64668048–65875491	-----
	11:21968768–29134515	ANO3
	11:115218677–120365028	BUD13, VPS11
	13:106701406–109091885	-----
	16:63079319–66386711	-----
P3	6:203878–460901	-----	0.1368	0.1393
	6:3446942–4470581	-----
	9:97466973–102213749	-----
	10:14311273–15844850	-----
	10:64668048–65875491	-----
	11:115218677–120365028	BUD13, TMEM25, VPS11
	13:106701406–109091885	-----
	16:63079319–66386711	CDH5
	16:81159781–83154022	MBTPS1

Genes were included if they were present in the linkage region (LR; ± 1 Mb) with LOD ≥ 2, to which the family was contributing and if they harbored a rare variant (according to our selection criteria).
^aNo variants were observed in the ANP32B gene in IMpACT exome-chip data. Gene-set-based association analysis used meta-analytic exome-chip data from 9365 individuals (1846 ADHD patients and 7519 controls [22]).

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