Table 4 Studies of amygdala
From: The neuropathology of bipolar disorder: systematic review and meta-analysis
Study | Sample (Con/BD) | Amygdalar nuclei investigated | Stain | Parameters measured | Key significant findings in BD |
|---|---|---|---|---|---|
Bowley et al. (2002) [34] | 10/12 | Not differentiated | Nissl | Neuronal and glial density | No differences |
Hamidi et al. (2004) [43] | 10/9 | Not differentiated | Nissl, S-100β, HLA | Glial density | No differences |
Bielau et al. (2005) [47] | 22/11 | Not differentiated | Nissl, myelin | Volume | No differences |
Berretta et al. (2007) [53] | 12/10 | Lateral, basal, accessory basal and cortical | Nissl | Volumes. Neuronal number, density and size. | Lateral nucleus: reduced volume (−29%), neuron number (−41%) and density (−14.5%). Accessory basal nucleus: reduced neuronal density (−21%). No other differences. |
Bezchlibnyk et al. (2007) [54] | 15/11 | Lateral, basal, and accessory basal (parvocellular and magnocellular) | Nissl | Neuronal and glial density. Neuronal and glial size. | Reduced neuronal size in lateral (− 29.7 %) and accessory basal parvocellular (− 28.3 %) nuclei. No differences in cell densities. |
Altshuler et al. (2010) [65] | 14/10 | Basolateral | Nissl, GFAP | Density of neurons and GFAP-positive astrocytes. | No differences |
Pantazopoulos et al. (2010) [70] | 15/11 | Lateral, basal, accessory basal and cortical | GFAP, PV | Number and density of PV-positive neurons. Number and density of GFAP-positive astrocytes. | No differences |
Pantazopoulos et al. (2017) [92] | 15/15 | Lateral, basal, accessory basal and cortical | NPY, SS | Volumes. Number and density of NPY- and SS-positive neurons. | Decreased volume of lateral (− 22%) and cortical (− 31%) nuclei. SS-positive neurons: decreased number (− 26%) and density in lateral nucleus. NPY-positive neurons: decreased number in cortical nucleus (− 29%). No other differences. |
