Table 2 Estimates for PiB-PET variables and APOEε4 carrier status predicting HADS-anxiety subscale scores in serial multivariate models

From: Association of anxiety with subcortical amyloidosis in cognitively normal older adults

Predictor

Unstandardized β-estimate (SE)

95% CI

Model R2

P-value

Series 1 (n = 118): neocortical PiB+/PiB− groups and APOEε4 carrier status

 PiB+ group (reference PiB−)

+ 0.2 (0.5)

− 0.9 to 1.3

0.16

0.73

 APOEε4 carrier (reference non-carrier)

+ 0.4 (0.6)

− 0.7 to 1.5

0.16

0.47

 PiB+ group * APOEε4 carrier

+ 2.3 (1.3)

− 0.3 to 4.9

0.19

0.07

Series 2 (n = 118): PiB stages (reference PiB stage 0) and APOEε4 carrier status

 PiB Stage 1

− 0.5 (0.6)

− 1.7 to 0.8

0.19

0.46

 PiB Stage 2

+ 1.8 (0.9)

0.1 to 3.6

0.04

 PiB Stage 1 * APOEε4 carrier

+ 1.2 (1.4)

− 1.5 to 3.9

0.24

0.38

 PiB Stage 2 * APOEε4 carrier

+ 4.3 (1.7)

1.0 to 7.6

0.01

Series 3 (n = 43): continuous PiB measures in neocortical PiB+ participants

 Neocortical PiB

+ 0.6 (1.0)

− 1.4 to 2.6

0.20

0.54

 Striatal PiB

+ 3.0 (1.6)

− 0.1 to 6.1

0.26

0.07

 Thalamus PiB

+ 6.7 (2.5)

1.7 to 11.7

0.32

0.01

 Amygdala PiB

+ 9.5 (4.0)

1.6 to 17.3

0.29

0.02

  1. Each row shows results for the predictor or predictors of interest in separate models. All models are adjusted for age, sex, education, MMSE, and GDS scores. PiB Stage 0 (low neocortical, low striatal PiB). PiB Stage 1 (high neocortical, low striatal PiB). PiB Stage 2 (high neocortical, high striatal PiB). CI confidence interval, GDS Geriatric Depression Scale, HADS-anxiety Hospital Anxiety and Depression Scale, MMSE Mini-Mental State Examination, PiB Pittsburgh Compound B
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