Table 1 Aggregate demographics

 Discovery cohort (within-subject changes in life stress VAS)

Low life stress VAS ≤ 33 to high life stress VAS ≥ 67

Concordance with 1 other item (health stress, financial stress, social stress)

36 (with 91 visits)

Male = 28

Female = 8

BP 14 (38)

MDD 7 (15)

PSYCH 1 (3)

PTSD 6 (16)

SZ 6 (14)

SZA 2 (5)

EA = 25

AA = 10

Hispanic = 1

All = 49.8022 (10.3754)

Low stress = 50.31

High stress = 49.30

 Independent validation cohort (clinically severe stress PCL-C ≥ 50; life stress VAS ≥ 67)

48 (75 visits)

Male = 35

Female = 13

MDD = 13

BP = 8

SZ = 2

SZA = 7

PTSD = 13

MOOD = 4

EA = 37

AA = 10

48.96 (8.4)

Discovery vs. validation 0.56523437

 Independent testing cohort for predicting state (high stress state life stress VAS ≥ 67 at the time of assessment)

122 (258 visits)

Male = 95

Female = 27

BP = 53

MDD = 24

SZA = 15

SZ = 17

PTSD = 9

MOOD = 1

PSYCH = 3

EA = 89

AA = 31

Mixed = 1

Hispanic = 1

All = 45.5 (9.93)

Others = 46.2

High Stress = 44.03

High stress (n = 38) vs. others (N = 220) 0.50720396

 Independent testing cohort for predicting trait (future hospitalizations with stress in the first year following assessment)

162 (398 visits)

Male = 144

Female = 18

BP = 50

MDD = 27

SZA = 32

SZ = 39

PTSD = 8

MOOD = 3

PSYCH = 8

EA = 101

AA = 58

Mixed = 1

Hispanic = 2

All = 50.4 (8.19)

Others = 48.6

Hosp with stress = 47.9

Hosp with stress (n = 32) vs. others (n = 366) 0.7001408

 Independent testing cohort for predicting trait (future hospitalizations with stress in all years following assessment)

186 (474 visits)

Male = 166

Female = 20

BP = 56

MDD = 30

SZA = 47

SZ = 39

PTSD = 8

MOOD = 3

PSYCH = 3

EA = 119

AA = 64

Mixed = 1

Hispanic = 2

All = 50.45 (8.86)

Others = 50.55

Hosp with Stress = 50.12

Hosp with stress (n = 113) vs. others (n = 361) 0.65942853