Table 3 Mean norepinephrine transporter methylation values (mean ± SD) for each site as well as the average for each promoter region.
ADHD | Controls | p-value | |
|---|---|---|---|
Region 1 | |||
CpG 1 | 0.59 ± 0.06 | 0.45 ± 0.16 | 0.001* |
CpG 2.3 | 0.50 ± 0.07 | 0.37 ± 0.17 | 0.02 |
CpG 4 | 0.29 ± 0.04 | 0.23 ± 0.09 | 0.004* |
CpG 5 | 0.13 ± 0.02 | 0.16 ± 0.05 | 0.007* |
CpG 6 | 0.16 ± 0.03 | 0.15 ± 0.04 | 0.1 |
CpG 7.8 | 0.09 ± 0.01 | 0.10 ± 0.03 | 0.03 |
CpG 9.10.11 | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.1 |
CpG 12.13 | 0.11 ± 0.02 | 0.13 ± 0.02 | 0.002* |
Total region 1 | 0.27 ± 0.03 | 0.22 ± 0.05 | 0.007* |
Region 2 | |||
CpG 2 | 0.11 ± 0.03 | 0.12 ± 0.02 | 0.1 |
CpG 3.4 | 0.07 ± 0.02 | 0.07 ± 0.01 | 0.1 |
CpG 5.6.7 | 0.06 ± 0.01 | 0.07 ± 0.03 | 0.1 |
CpG 8.9.10 | 0.05 ± 0.02 | 0.06 ± 0.03 | 0.1 |
CpG 11.12 | 0.03 ± 0.01 | 0.03 ± 0.02 | 0.04 |
CpG 13 | 0.03 ± 0.02 | 0.04 ± 0.04 | 0.1 |
CpG 14.15.16 | 0.10 ± 0.03 | 0.10 ± 0.01 | 0.1 |
CpG 19.20.21 | 0.03 ± 0.01 | 0.04 ± 0.01 | 0.1 |
CpG 22.23.24 | 0.06 ± 0.03 | 0.06 ± 0.02 | 0.1 |
CpG 25 | 0.04 ± 0.03 | 0.04 ± 0.04 | 0.1 |
CpG 26.27 | 0.07 ± 0.02 | 0.06 ± 0.02 | 0.1 |
CpG 29.30 | 0.06 ± 0.03 | 0.06 ± 0.02 | 0.1 |
CpG 31.32.33.34 | 0.05 ± 0.03 | 0.06 ± 0.03 | 0.1 |
CpG 41.42 | 0.02 ± 0.02 | 0.02 ± 0.02 | 0.1 |
CpG 43.44.45 | 0.08 ± 0.04 | 0.08 ± 0.04 | 0.1 |
CpG 49.50.51.52 | 0.05 ± 0.01 | 0.04 ± 0.01 | 0.1 |
CpG 53 | 0.03 ± 0.01 | 0.03 ± 0.01 | 0.1 |
CpG 54.55 | 0.02 ± 0.01 | 0.04 ± 0.05 | 0.006* |
Total region 2 | 0.05 ± 0.01 | 0.05 ± 0.02 | 0.1 |
Region 3 | |||
CpG 1.2 | 0.02 ± 0.00 | 0.04 ± 0.03 | 0.001* |
CpG 3.4 | 0.02 ± 0.01 | 0.04 ± 0.03 | 0.002* |
CpG 7 | 0.03 ± 0.01 | 0.03 ± 0.01 | 0.1 |
CpG 8.9 | 0.09 ± 0.02 | 0.11 ± 0.03 | 0.03 |
CpG 10 | 0.02 ± 0.01 | 0.04 ± 0.03 | 0.05 |
CpG 11 | 0.06 ± 0.02 | 0.07 ± 0.03 | 0.1 |
CpG 12 | 0.04 ± 0.01 | 0.05 ± 0.02 | 0.1 |
Total region 3 | 0.04 ± 0.01 | 0.05 ± 0.02 | 0.03 |
