Table 2 Clinical data for all samples included in the ENIGMA-MDD-DTI project: percentage of MDD patients using antidepressants, percentage of acute versus remitted MDD, age of onset of MDD, percentage of MDD patients with a comorbid anxiety disorder and severity of MDD symptoms, presented separately for adult (age > 21) and adolescent (age ≤ 21) samples
Study | Sample | % AD use | % first episode/recurrent MDD | % Acute/remitted MDD | Age of onset MDD (mean ± SD) | % comorbid anxiety disorder | HDRS-17 severity MDD (mean ± SD)a | BDI-II severity MDD (mean ± SD)b |
|---|---|---|---|---|---|---|---|---|
Adult samples | ||||||||
1 | Barcelona | 94.50 | 32.70/67.30 | 63.60/36.40 | 32.91 ± 11.45 | 0.0 | 13.51 ± 9.04 | NA |
2 | Bipolar family study | 16.70 | NA | NA | 22.80 ± 2.70 | NA | 4.94 ± 4.72 | NA |
3 | CODE | 0.00 | 0.00/100.00 | 100.00/0.00 | NA | NA | NA | NA |
4 | DIP | 50.00 | 31.25/68.75 | 100.00/0.00 | 26.00 ± 13.46 | 31.3 | NA | 25.94 ± 10.03 |
5 | Sexpect | 100.00 | 20.00/80.00 | 100.00/0.00 | 30.87 ± 11.24 | 0.1 | 11.90 ± 5.39 | 20.86 ± 12.40 |
6 | MOTAR | 0.00 | 71.00/29.00 | 100.00/0.00 | 24.52 ± 9.93 | 45.2 | NA | NA |
7 | MPIP | NA | 0.00/100.00 | 70.00/30.00 | 32.20 ± 12.76 | 17.9 | NA | 14.25 ± 10.87 |
8 | FOR2017 | 60.60 | 22.50/75.70 | 73.90/21.10 | 27.34 ± 13.12 | 12.0 | 8.85 ± 8.00 | 17.58 ± 11.16 |
9 | Munster neuroimaging cohort | 88.80 | 22.40/77.60 | 100.00/0.00 | 30.15 ± 12.13 | NA | 23.09 ± 5.15 | 28.56 ± 9.16 |
10 | NESDA | 33.90 | 6.80/93.20 | 37.30/62.70 | 25.44 ± 10.60 | 23.7 | NA | NA |
11 | Novosibirsk | 18.80 | 60.40/39.60 | 100.00/0.00 | 38.60 ± 14.16 | 0.0 | 18.41 ± 4.75 | 31.73 ± 10.87 |
12 | QTIM | NA | NA | NA | 19.54 ± 4.74 | 30.8 | NA | NA |
13 | Stanford | 21.40 | 0.00/100.00 | 100.00/0.00 | 16.79 ± 6.34 | 64.3 | 18.86 ± 4.22 | 29.71 ± 6.41 |
14 | Sydney | 40.30 | 31.30/31.30 | 40.30/35.80 | 14.11 ± 7.39 | 26.9 | 12.48 ± 7.26 | 4.00 ± 3.39 |
15 | Imaging Genetics Dublin | 75.50 | 0.00/100.00 | 100.00/0.00 | 25.26 ± 12.67 | NA | 23.53 ± 5.00 | 33.17 ± 11.60 |
16 | IMH MDD Singapore | 100.00 | 34.80/65.20 | 21.70/78.30 | 33.39 ± 9.83 | NA | 6.30 ± 6.23 | NA |
Adolescent samples | ||||||||
1 | Child and Adolescent Imaging Research Calgary | 65.00 | 0.00/100.00 | 100.00/0.00 | 14.10 ± 2.29 | 79.3 | 20.40 ± 6.31 | 30.50 ± 10.51 |
2 | EPISCA | 11.80 | 100.00/0.00 | 100.00/0.00 | NA | 29.4 | NA | NA |
3 | University of Minnesota | 23.50 | 23.59/32.40 | NA | 12.46 ± 2.35 | 63.3 | NA | 26.35 ± 12.06 |
4 | FOR2017 | 60.00 | 24.00/76.00 | 80.00/20.00 | 14.21 ± 2.96 | 17.6 | 11.45 ± 9.17 | 19.13 ± 12.02 |
5 | Munster neuroimaging cohort | 84.60 | 53.80/46.20 | 100.00/0.00 | 16.77 ± 2.89 | NA | 22.38 ± 3.86 | 30.08 ± 10.40 |
6 | QTIM | NA | NA | NA | 17.92 ± 2.10 | 46.2 | NA | NA |
7 | Sydney | 41.90 | 29.00/32.30 | 46.50/31.00 | 11.57 ± 5.52 | 23.2 | 12.65 ± 7.86 | 2.31 ± 0.95 |
8 | UCSF | 0.00 | 35.09/64.91 | 92.99/7.01 | 13.40 ± 2.34 | 61.0 | NA | 28.33 ± 11.12 |
