Table 1 Annotations for SNPs that showed significant and consistent impacts in both SH-SY5Y and SK-N-BE(2) cell lines by PASSPORT-seq

From: Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

Region

Gene

SNP

MAF (%)

eQTL

RBP binding

Potential miRNA target

BLA

PEAK1

rs17381821

18

Yes

 

miR-3913-3pa

BLA

PNP

rs1079375

32

Yes

  

CE

HELQ

rs4693089

34

Yes

PABPC1, ELAVL1

 

CE

KIF1B

rs1065828

33

Yes

IGF2BP1

 

CE

KIF1B

rs1536262

45

Yes

IGF2BP1

 

CE

PACRGL

rs6812257

31

Yes

ELAVL1, PABPC1

 

CE

ZNF625

rs59816741

1

No

  

NAC

LYPD5

rs4525602

3

No

  

NAC

PCDHB16

rs2338530

10

Yes

PABPC1

 

NAC

PRLR

rs173627

24

No

PABPC1

 

NAC

SLC16A4

rs11120

18

Yes

ELAVL1, PABPC1

miR-200b-3pb, miR-200c-3pa, miR-374c-5pa, miR-429c, miR-4330b, miR-510-5pa, miR-512-5pb, miR-655-3pb, miR-8084a, miR-3942-3pc, miR-506-5pc, miR-5100b, miR-6074a, miR-889-3pc, miR-892c-5pa

NAC

SMPD4

rs10909567

38

Yes

IGF2BP1

 

NAC

SYT9

rs10732510

48

No

 

miR-3925-3pb, miR-136-5pc, miR-4695-3pa, miR-665a, miR-766-3pc

SFC

CA13

rs4617148

45

Yes

ELAVL1, PABPC1, IGF2BP1

miR-3125c, miR-3916c, miR-6859-5pa, miR-6866-5pa, miR-877-5pc, miR-4496c

SFC

CA13

rs4740047

42

Yes

ELAVL1, PABPC1, IGF2BP1

 

SFC

FKTN

rs2010861

13

Yes

ELAVL1, PABPC1

miR-6840-3pa

SFC

LRPAP1

rs11723071

20

Yes

  

SFC

LRPAP1

rs11729369

25

Yes

  

SFC

LRPAP1

rs13325

13

No

  

SFC

LRPAP1

rs140653273

1

No

  

SFC

MAVS

rs6515831

31

Yes

 

miR-4289a

SFC

PODN

rs899974

19

No

  

SFC

PPARA

rs10154348

7

Yes

ELAVL1, PABPC1, CELF1

miR-7155-5pa

SFC

SNX18

rs2565014

35

Yes

PABPC1

miR-4655-3pa

miR-7848-3pa

SFC

UQCC1

rs3764732

14

No

PABPC1

miR-3922-5pa, miR-513c-5pb, miR-514b-5pc, miR-330-3pc, miR-371a-5pa, miR-371b-5pc, miR-372-5pa, miR-373-5pb, miR-616-5pc, miR-7109-3pa

  1. Brain regions: BLA basolateral nucleus of the amygdala, CE central nucleus of amygdala, NAC nucleus accumbens, SFC superior frontal cortex. MAF minor allele frequency, eQTL whether the SNP had a significant eQTL for its gene in GTEx, RBP RNA-binding proteins whose binding sites overlapped the SNP, and miRNAs whose binding potential was changed by the alternative allele
  2. amiRNA expression unknown
  3. bmiRNA not expressed in brain
  4. cmiRNA expressed in brain