Table 1 A table of loci from the PGC study [42] overlapping a genomic regulatory block, with target genes assigned to each locus by the GWAS study and by the GRB method

From: Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks

Locus coordinates	GWAS SNPs	GWAS genes	GRB target genes	GRB by stander genes
chr5:60499143–60843543	rs4391122	ZSWIM6	SMIM15	NDUFAF2,ZSWIM6,RPL3P6,C5orf64,RNU6-913P,RN7SKP157
chr2:200715237–200848037	chr2_200825237_I	AC073043.2 C2orf47 C2orf69 TYW5	SATB2	PLCL1,RNU7-147P,SATB2-AS1,SEPHS1P6,FTCDNL1
chr7:110843815–111205915	rs13240464	IMMP2L	LRRN3	IMMP2L,DOCK4,DOCK4-AS1
chr11:130714610–130749330	rs10791097	SNX19	ADAMTS15,NTM,OPCML,SPATA19,IGSF9B	ADAMTS8,BAK1P2,C11orf44,PPP1R10P1,SNX19,RN7SL167P,RNU6ATAC12P,NTM-IT,RNU6-1182P,OPCML-IT2,OPCML-IT1,MIR4697,JAM3
chrX:21193266–21570266	rs1378559	CNKSR2	KLHL34	CNKSR2,SMPX
chr18:52747686–53200117	chr18_52749216_D, rs78322266, rs9636107	TCF4	CCDC68	RAB27B,MAP1LC3P,RNA5SP459,TCF4,MIR4529,RPL21P126
chr3:180588843–181205585	chr3_180594593_I, rs9841616	CCDC39 DNAJC19 FXR1	SOX2	FXR1,DNAJC19,SOX2-OT,RNU6-4P,FAUP2,RPL7AP25,RN7SL703P,RNA5SP150,RN7SKP265,RPL7L1P8
chr2:57943593–58502192	rs11682175, rs75575209	FANCL VRK2	BCL11A	VRK2,FANCL,EIF3FP3,LINC01122,RNU6-508P,RNA5SP94,RNU1-32P,MIR4432,RN7SL361P,RNU6-612P,ATP1B3P1,PAPOLG
chr18:53453389–53804154	rs72934570, rs715170	TCF4*	CCDC68	RAB27B,MAP1LC3P,RNA5SP459,TCF4,MIR4529,RPL21P126
chr3:2532786–2561686	rs17194490	CNTN4	CNTN6	RN7SL120P,RPL23AP39,RPL21P17,RN7SKP144,CNTN4,CNTN4-AS2,DNAJC19P4,CNTN4-AS1,IL5RA
chr3:52541105–52903405	rs2535627	GLT8D1 GNL3 ITIH1 ITIH3	SEMA3G,TNNC1,NT5DC2	PHF7,NISCH,STAB1,SMIM4,PBRM1,RNU6-856P,RNU6ATAC16P
chrX:68377126–68379036	rs5937157	PJA1	EFNB1,FAM155B	STARD8,ACTR3P2,SERBP1P1,PJA1,HMGN1P35,LINC00269,CYCSP43,EDA
chr17:2095899–2220799	rs4523957	SGSM2 SMG6 SRR TSR1	SCARF1,RILP,TLCD2,SERPINF2,RTN4RL1,HIC1,MNT	SLC43A2,RN7SL105P,PRPF8,MIR22HG,WDR81,SERPINF1,SMYD4,RPA1,DPH1,OVCA2,MIR132,MIR212,SMG6,RN7SL624P,SRR,HNRNPA1P16,TSR1,SNORD91B,SNORD91A,SGSM2,METTL16
chr15:61831663–61909663	rs12903146	VPS14C*	RORA	NARG2,CYCSP38,RNA5SP397
chr22:42315744–42689414	rs1023500, rs6002655	CENPM CYP2D6 FAM109B NAGA NDUFA6 SEPT3 SHISA8 SMDT1 SREBF2 TCF20 TNFRSF13C WBP2NL	NFAM1	TCF20
chr2:146416922–146441832	chr2_146436222_I		ARHGAP15,ZEB2	KYNU,MTND6P11,MTND5P24,MTND4P22,MTND3P9,GTDC1,ZEB2-AS1,TEX41,RPL6P5,RNU7-2P,RPL17P12,PABPC1P2
chr1:243503719–244002945	rs10803138, rs77149735, rs14403, chr1_243881945_I	AKT3 SDCCAG8	ZBTB18	SDCCAG8,MIR4677,AKT3,FABP7P1,AKT3-IT1,RN7SL148P
chr3:17221366–17888266	rs4330281	TBC1D5	SATB1	TBC1D5,PDCL3P3,RAD23BP1,RNU6-138P
chr8:60475469–60954469	rs6984242	CA8*	TOX	RNU4-50P,RNA5SP267,SLC2A13P1,CA8
chr14:30189985–30190316	rs2068012	PRKD1	FOXG1	C14orf23,RNU6-864P,RNU11-5P,PRKD1,RNU6-1234P
chr4:23366403–23443403	rs215411	MIR548AJ2*	PPARGC1A,DHX15,SOD3	GBA3,CDC42P6,RFPL4AP3,MIR573,RN7SL16P,ATP5LP3,HNRNPA1P65,CCDC149,LGI2
chr7:110034393–110106693	rs211829	IMMP2L*	LRRN3	IMMP2L,DOCK4,DOCK4-AS1
chr7:131539263–131567263	rs7801375	PODXL*	PLXNA4,LRGUK	CHCHD3,EXOC4,COX5BP3,SLC35B4
chr1:177247821–177300821	rs6670165	FAM5B	ASTN1,BRINP2,SEC16B	PAPPA2,PTP4A1P7,MIR488,RASAL2-AS1,RASAL2
chr1:207912183–208024083	rs7523273	C1orf132 CD46 CR1L	PLXNA2	C1orf132,CD34,RPS26P13,ATP5G2P1,MIR205HG
chr12:92243186–92258286	rs4240748	C12orf79*	BTG1	C12orf79,RPL21P106
chr12:103559855–103616655	rs10860964	C12orf42	PAH,ASCL1	IGF1,LINC00485,RNU7-184P,C12orf42

Only a subset with completely novel target genes by the GRB method proposed is presented here; for the full set of loci from the PGC dataset, see Supplementary Table S1
*Denotes nearest non-overlapping gene to the locus, as defined in the Supplementary Table S3 in [42]

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Table 1 A table of loci from the PGC study [42] overlapping a genomic regulatory block, with target genes assigned to each locus by the GWAS study and by the GRB method

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