Table 1 Associations between polygenic scores for major depressive disorder (MDD) and loneliness with coronary artery disease (CAD) after excluding patients with a diagnosis of MDD, depressive symptoms, or any psychiatric symptoms
Polygenic score | Patient exclusions | N Cases with CAD | N Controls without CAD | OR (95% CI) | P |
|---|---|---|---|---|---|
MDD | None | 3893 | 4197 | 1.11 (1.04–1.18) | 8.43 × 10−4 |
MDD | MDD | 3744 | 4037 | 1.11 (1.05–1.18) | 6.54 × 10−4 |
MDD | Depressive symptoms | 2935 | 3147 | 1.10 (1.03–1.18) | 5.76 × 10−3 |
MDD | Any psychiatric symptoms | 2440 | 2551 | 1.11 (1.03–1.19) | 9.27 × 10−3 |
Loneliness | None | 3893 | 4197 | 1.13 (1.08–1.20) | 4.51 × 10−6 |
Loneliness | MDD | 3744 | 4037 | 1.13 (1.07–1.20) | 9.22 × 10−6 |
Loneliness | Depressive symptoms | 2935 | 3147 | 1.14 (1.08–1.22) | 2.08 × 10−5 |
Loneliness | Any psychiatric symptoms | 2440 | 2551 | 1.12 (1.05–1.20) | 8.69 × 10−4 |
