Table 2 Differences in regional 5-HTT availability.

From: Serotonin transporter availability in adults with autism—a positron emission tomography study

   

ASD

  

Control

    

Region of interest

n

Mean

SD

n

Mean

SD

p

Difference

Neocortex

15

0.18

0.04

15

0.22

0.05

0.02*

−16.4%

Frontal cortex

15

0.16

0.04

15

0.20

0.06

0.02*

−19.2%

Occipital cortex

14

0.23

0.06

14

0.26

0.06

0.13

−11.2%

Parietal cortex

15

0.19

0.04

15

0.23

0.05

0.02*

−16.8%

Temporal cortex

15

0.21

0.07

15

0.24

0.06

0.08

−15.7%

Orbitofrontal cortex

13

0.20

0.08

13

0.23

0.10

0.48

−11.4%

Rostral middle frontal cortex

14

0.09

0.04

14

0.12

0.05

0.02*

−27.4%

Fusiform cortex

15

0.27

0.08

15

0.31

0.09

0.08

−13.9%

Insular cortex

15

0.55

0.08

15

0.62

0.11

0.03*

−11.7%

Anterior cingulate cortex

15

0.37

0.06

15

0.46

0.09

0.008*

−19.7%

Posterior cingulate cortex

14

0.30

0.08

14

0.36

0.08

0.02*

−17.1%

Amygdala

14

1.00

0.19

14

1.02

0.18

0.79

−1.8%

Hippocampus

15

0.53

0.13

15

0.57

0.15

0.46

−6.9%

Nucleus accumbens

14

1.03

0.21

14

1.18

0.25

0.03*

−13.1%

Caudate

15

0.63

0.12

15

0.71

0.11

0.12

−11.4%

Putamen

15

1.07

0.15

15

1.23

0.16

0.02*

−12.5%

Pallidum

15

1.20

0.27

15

1.22

0.22

0.80

−1.6%

Thalamus

15

1.05

0.14

15

1.13

0.15

0.10

−7.5%

Brainstem

15

0.73

0.17

15

0.86

0.15

0.008*

−15.0%

  1. 5-HTT availability (BPND) in 18 subregions of gray matter and brainstem. Group mean and standard deviation (SD). Paired-sample t test. Presented numbers are not corrected for multiple comparisons.
  2. *Significant after correction for multiple comparisons.
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